This meme includes a play on the semi-common meme trope of wanting to smell “girlstink” (which is fem-presenting body odour) which is “stinky in the good way, because the writer of the meme is horny for girlstink”

Thus taking said “girlstink” trope, which would have the body odour smell given sparkles because it’s magical to the downbad meme writer (and possibly reader), and replacing the character that’s “smelly” with GLaDOS from the classic games Portal and Portal 2 - whomst is well known (in the circles worth being in) for having the significant desire to release deadly neurotoxin - we get the remix of the “girlstink” meme trope. The character representing you (the reader) is sniffing the “girlstink” and is sweaty in a horny way for the “girlstink” from GLaDOS and her deadly neurotoxin that is being blown to you with a comical fan mechanism. But you’re also probably sweating from the deadly neurotoxin killing you.

Now if you’ve played a Portal game, please read this text in GLaDOS’ voice: “it’s your old friend, deadly neurotoxin.” Just to get in the “negged by a disembodied voice that’s a dommy mommy robot” mood.